The impact of atmospheric pollution on vitamin D status of infants and toddlers in Delhi, India. 2005 135:317–322.Īgarwal KS, Mughal MZ, Upadhyay P, Berry JL, Mawer EB, Puliyel JM. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. Prevention of rickets and vitamin D deficiency in infants, children and adolescents. Hypovitaminosis D in a sunny country: relation to lifestyle and bone markers. Gannage-Yared MH, Chemali R, Yaacoub N, Halaby G. Vitamin D and bone mineral density status of healthy school children in northern India. Marwaha RK, Tandon N, Reddy DHK, Agrawal R, Singh R, Sawhney RC, et al. Vitamin D status of apparently healthy schoolgirls from two different socioeconomic strata in Delhi: relation to nutrition and lifestyle. Puri S, Marwaha RK, Agrawal N, Tandon N, Agrawal R, Grewal K, et al. Vitamin D Deficiency in Indian adolescents. Impact of two regimens of vitamin D supplementation on calcium-vitamin D-PTH axis of school girls of Delhi. Marwaha RK, Tandon N, Agrawal N, Puri S, Agrawal R, Singh S, et al. Vitamin D deficiency in children and adolescents: Epidemiology, impact and treatment. Vitamin D deficiency in a healthy group of mothers and newborn infants. Lee JM, Smith JR, Philipp BL, Chen TC, Mathieu J, Holick MF. Prevalence of vitamin D deficiency among healthy infants and toddlers. Gordon CM, Feldman H, Sinclair L, Williams A, Cox J. Prevalence of vitamin D deficiency among healthy adolescents. Gordon CM, DePeter KC, Feldman HA, Grace E, Emans SJ. The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action. Vitamin D deficiency in children and it’s management: Review of current knowledge and recommendations. Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M. The miracle of vitamin D: sound science or hype? NY Times 2010 Feb 1. There is a need for large randomized clinical trials to investigate the nonskeletal benefits of vitamin D deficiency. Widespread subclinical and pre-rachitic vitamin D deficiency in children should be diagnosed by serum 25(OH)D levels and these levels should be maintained above 20 ng/mL to obtain optimal health benefits. Though some evidence suggests a role of hypovitaminosis D in pathophysiology of many clinical situations other than rickets and osteomalacia like autoimmune diseases, cardiovascular diseases, infections, cancers, fetal health, and exercise performance, some authorities feel there is a lack of unequivocal evidence in favour of nonskeletal health benefits of vitamin D. Vitamin D deficiency is highly prevalent throughout the world including India. Latest editions of standard texts were also searched. Emphasis was placed on pediatric literature, although sentinel adult studies relevant to this article have been included. Reference lists of all articles were also reviewed. All articles having direct relevance to to the present review were searched. The literature search was limited to articles in last 35 years and written in the English language. We performed a literature search using PubMed/medline, EMBASE and ScienceDirect databases indexed under the Medical Subject Heading (MeSH) terms “Vitamin D OR Vitamin D deficiency” combined with the terms “children” OR “pediatric” OR “child health”. Sensitizing pediatricians to widespread vitamin D deficiency in children and benefits accrued from it’s correction would go a long way as far as clinical practice and public health is concerned. Recent evidence indicates that today the world is facing vitamin D deficiency pandemic. Vitamin D has emerged as a topic of great interest among researchers.
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